|
KMID : 0356720010170030141
|
|
Journal of the Korean Society of Coloproctology
2001 Volume.17 No. 3 p.141 ~ p.147
|
|
|
Occurrence and Prognostic Implications of Lymph Node Micrometastases in Patients with Dukes’ B Colorectal Carcinoma
|
|
Choi Yun-Young
Choi Hong-Jo
Jung Ghap-Joong
Kim Sang-Sun
Hong Sook-Hee
|
|
|
Abstract
|
|
|
Purpose: Whereas lymph node metastases in colorectal carcinoma are important prognostic factor, the prognostic relevance of occult tumor cells in lymph nodes has not been elucidated yet. Aims of this study were to assess the incidence of micrometastases of lymph nodes in patients with Dukes’ B colorectal carcinoma and to investigate the correlation between nodal micrometastases and malignant potential to determine whether micrometastases of lymph nodes have prognostic significance, using an anti-cytokeratin immunohistochemical technique.
Methods: To evaluate the incidence of lymph node micrometastases in patients with Dukes’ B colorectal carcinoma, 1160 lymph nodes taken from 65 patients (17.9 per case) were assessed by immunohistochemical technique using a monoclonal anti-human cytokeratin (MNF 116). Clinicopathologic parameters and survival rate were compared between patients with and without micrometastases.
Results: The incidence of nodal involvement by tumor cells in 65 patients with Dukes’ B colorectal carcinoma (41 colon, 22 rectum, 2 synchronous cancer) was 30.8% (20 cases) and nodal positivity 3.2% (33/1423 nodes) by the immunostaining. No correlations were observed between the incidence of cytokeratin positivity and various clinicopathologic parameters, including preoperative CEA level, tumor site and size, histologic differentiation, pT stage, vascular invasion and lymphatic invasion and rate of recurrence. There was no difference in five-year survival estimated by Kaplan-Meier lifetable method between the micrometastases negative and positive groups (94.8% and 94.1%, respectively).
|
|
|
KEYWORD
|
|
|
Colorectal cancer, Micrometastasis, Lymph node
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|
|